BAX antibody (AA 41-76)
Quick Overview for BAX antibody (AA 41-76) (ABIN2797999)
Target
See all BAX AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 41-76
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Purpose
- Rabbit Anti-Human Bax (BH3 Domain Specific) Antibody
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Immunogen
- This Bax antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-76 amino acids from human Bax.
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Isotype
- Ig Fraction
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Application Notes
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Western Blot, Immunohistochemistry, Flow Cytometry
Recommended Dilutions
WB: 1:1000, IHC: 1:50-100, FC: 1:10-50Bax Antibody(BH3) with the Bax gene. -
Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1.600 mg/mL
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Storage
- 4 °C,-20 °C
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Storage Comment
- 2-8°C (short-term), -20°C (long-term)
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- BAX (BCL2-Associated X Protein (BAX))
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Alternative Name
- Bax
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Background
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Target Description: Bax belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Bax forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of the Bax gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis.
Gene Symbol: BAX
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Molecular Weight
- 21184 Da
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Gene ID
- 581
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UniProt
- Q07812
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Pathways
- p53 Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
Target
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